WebSynonyms: INC-280 2HCl, INCB28060 2HCl, INCB28060盐酸盐. INCB-28060 (free base) is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM.INCB28060 exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10, 000-fold selectivity over a large panel of human kinases. WebCapmatinib (INCB28060) Catalog Number: M2080: CAS Number: 1029712-80-8: 1.2 Relevant identified uses of the substance or mixture and uses advised against; Identified …
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WebJul 15, 2024 · SECTION 1: Identification 1.1 GHS Product identifier Product name 2-fluoro-N-methyl-4- [7- (quinolin-6-ylmethyl)imidazo [1,2-b] [1,2,4]triazin-2-yl]benzamide 1.2 Other means of identification 1.3 Recommended use of the chemical and restrictions on use 1.4 Supplier's details 1.5 Emergency phone number SECTION 2: Hazard identification WebMar 5, 2024 · INCB28060 (INC280) Treatment. I. Recruiting. Solid tumors NCT01324479 INCB28060 (INC280) Safety. I. Recruiting. Japanese Patients with Advanced Solid Tumors NCT01546428 INCB28060 (INC280) Safety/Efficacy. IB/II. Active, Not Recruiting. NSCLC, EGFR-mutated, c-MET-amplified, EGFR-inhibitor insensitive. Gefitinib. NCT01610336 … how to run oig
INCB28060 - Creative Enzymes
WebOct 11, 2024 · All three drug candidates also showed inhibitory properties, but INCB28060 and Darglitazone Sodium had the greatest anti-SARS-CoV-2 activity. Interestingly, Columbianadin is proven to have ... WebMay 27, 2024 · Capmatinib (INCB28060) is a highly potent and selective MET inhibitor that blocks c-MET phosphorylation in lung cancer cell lines at half-maximal inhibitory concentration values of 0.3 to 0.7 nmol/L. 14 In the phase II GEOMETRY mono-1 trial, patients with MET exon 14 skipping alterations and various levels of copy-number gain … WebINCB28060 is a potent and selective c-MET kinase inhibitor that may have therapeutic potential in Cancer treatment. Products Cat. No. Product Name Description Target … how to run off s mode