Sumo chains: polymeric signals

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August undefined, 2024

Websignals for proteasome-mediated degradation. Together, these findings suggest multiple, proteasome-independent roles for SUMOs in the cellular response to the accumulation of … Web1 Feb 2024 · The SUMO-targeted ubiquitin ligases (STUbLs) RING-finger protein 4 (RNF4) and RNF111 recognize SUMO polymers in a chain-architecture-dependent manner, leading …

The Fast-Growing Business of SUMO Chains - ScienceDirect

Web13 Nov 2024 · In some cases, polymeric SUMO chains serve as a recognition signal for SUMO-targeted Ub ligases (STUbLs), which attach Ub moieties on the SUMOylated … Web1 Dec 2009 · Polyubiquitin chains: polymeric protein signals. Curr. Opin. Chem. Biol. 8, 610-616. Potts, P. R. (2009). The Yin and Yang of the MMS21-SMC5/6 SUMO ligase complex in … incommon root ca

SUMO2 - Small ubiquitin-related modifier 2 precursor

Webon ubiquitin polymers, we are still limited in our understanding of signaling by SUMO polymers. Highlights STUbLs recognize the composition of SUMO chains as … Web28 Feb 2010 · Title: SUMO chains: polymeric signals: Author: Vertegaal, A.C.O. Date issued: 2010-02-28: Access: Closed Access: Language: English: Type: Article: Abstract: Ubiquitin … Web1 Feb 2010 · SUMO chains: Polymeric signals SUMO chains: Polymeric signals February 2010 Authors: Alfred C O Vertegaal Request full-text Abstract Ubiquitin and ubiquitin-like … incommon root certificate download

[PDF] SUMO chains: polymeric signals. Semantic Scholar

Expanding SUMO and ubiquitin-mediated signaling through hybrid …

WebMonomeric and polymeric forms of SUMO and ubiquitin are covalently ... SUMO-Ub chains may also function as signals that affect lysosomal . ... Hybrid suMo-ub chain receptors. … WebSUMO chain formation is reversible; SUMO polymers are disassembled by SUMO proteases both in vitro and in vivo. SUMO chains play roles in replication, in the turnover of SUMO … inches off swimwear.comWeb11 Jan 2012 · The SUMO monomers display homogeneous fluorescence spots at the single-molecule level, whereas the mixed SUMO chains exhibit non-uniform fluorescence spots … incommon rsa server ca

"Web27 Jun 2014 · The small ubiquitin-like modifier (SUMO) can form polymeric chains that are important signals in cellular processes such as meiosis, genome maintenance and stress … " - Sumo chains: polymeric signals

Sumo chains: polymeric signals

SUMO polymeric chains are involved in nuclear foci formation and ...

Web11 Oct 2010 · The role SUMO plays in meiosis remains largely unknown; however, immunolocalization studies in mammals have detected SUMO at sites of double strand breaks (DSBs) and at centromeric and heterochromatic regions, including the XY body of mouse pachytene spermatocytes [ 9, 10, 11, 12 ]. WebSUMO (small ubiquitin-related modifier) shares the ability of ubiquitin to form chains via internal SUMOylation sites. Interestingly, a SUMO-binding site in Ubc9 is important for …

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WebPost-translational modification by SUMO is a dynamic and reversible process and several SUMO-specific proteases that remove SUMO from substrates have been identified. We …

Web22 Feb 2012 · Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins ( PubMed: … Web1 Feb 2010 · SUMO chains: polymeric signals. Ubiquitin and ubiquitin-like proteins are conjugated to a wide variety of target proteins that play roles in all biological processes. …

Web28 Feb 2010 · Interestingly, a SUMO-binding site in Ubc9 is important for SUMO chain synthesis. Similar to ubiquitin-polymer cleavage by USPs (ubiquitin-specific proteases), … WebHere, we developed a novel approach for analyzing polymeric SUMO2/3 chain signals by transfecting cells with the DNA construct encoding GFP-tagged four tandem SUMO …

WebC. M. Guzzo, RNF4-dependent hybrid SUMO-ubiquitin chains are signals for RAP80 and thereby mediate the recruitment of BRCA1 to sites of DNA damage. Sci. ... This is an …

WebThe SUMO monomers display homogeneous fluorescence spots at the single-molecule level, whereas the mixed SUMO chains exhibit nonuniform fluorescence spots with a wide … incommon rsa server ca downloadWeb1 Feb 2010 · Search worldwide, life-sciences literature Search. Advanced Search Coronavirus articles and preprints Search examples: "breast cancer" Smith J incommon shampooWeb16 Jan 2016 · In this mechanism, a tandem array of SUMO interaction motifs (SIMs) in STUbLs enables them to selectively ubiquitylate target proteins that are modified by … incommon server caWebInvestigations into the biological role of polymeric chains have been hampered by the absence of a protocol for the purification of proteins linked to SUMO chains. In this paper, … incommon shibbolethWebTarget proteins are conjugated to ubiquitin monomers or to ubiquitin polymers that form via all seven internal lysine residues of ubiquitin. The fate of these target proteins is … incommon rsa server ca certificate downloadWeb1 Apr 2024 · Unfortunately, the capture of interactors such as RNF4 and RNF111 using diSUMO-2 pull-down probes proved very difficult (data shown below), mainly because the … inches off swimsuitsWebPosttranslational modification of proteins by the small ubiquitin-like modifier (SUMO) is a potent regulator of various cellular events. Hundreds of substrates have been identified, … incommon ssl